InnateDB Protein
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IDBP-239417.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGPAT1
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Protein Name
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1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
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Synonyms
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1-AGPAT1; G15; LPAAT-alpha; LPAATA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378875
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InnateDB Gene
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IDBG-80399 (AGPAT1)
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Protein Structure
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Function |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269PubMed:21873652}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:21873652}; Multi-pass membrane protein {ECO:0000269PubMed:21873652}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver. {ECO:0000269PubMed:21873652}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003841
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1-acylglycerol-3-phosphate O-acyltransferase activity
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GO:0016746
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transferase activity, transferring acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002123
Phospholipid/glycerol acyltransferase
IPR004552
1-acyl-sn-glycerol-3-phosphate acyltransferase
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PFAM |
PF01553
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PRINTS |
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PIRSF |
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SMART |
SM00563
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TIGRFAMs |
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Modification |
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SwissProt |
Q99943
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PhosphoSite |
PhosphoSite-Q99943
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TrEMBL |
Q9HBM8
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UniProt Splice Variant |
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Entrez Gene |
10554
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UniGene |
Hs.409230
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RefSeq |
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HUGO |
HGNC:324
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OMIM |
603099
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CCDS |
CCDS4744
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HPRD |
04372
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IMGT |
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EMBL |
AF007145
AF218034
AK315950
AL662828
AL662884
AL845464
BC002402
BC003007
BC004310
BC090849
BX284686
BX927239
CH471081
CR812478
CR933878
U56417
U75971
U89336
Y09565
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GenPept |
AAB47493
AAB58775
AAB96378
AAC19153
AAG17276
AAH02402
AAH03007
AAH04310
AAH90849
BAH14321
CAA70758
CAI17430
CAI18347
CAI41807
CAM26221
CAQ06593
CAQ09622
CAQ10697
EAX03600
EAX03601
EAX03602
EAX03603
EAX03604
EAX03605
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