Version 5.4
Homo sapiens Gene: AGPAT1
Summary
InnateDB Gene IDBG-80399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGPAT1
Gene Name 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
Synonyms 1-AGPAT1; G15; LPAAT-alpha; LPAATA
Species Homo sapiens
Ensembl Gene ENSG00000204310
Encoded Proteins
IDBP-80401
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-80403
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-80405
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-239415
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-239417
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-239419
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32168212-32178096
Strand Reverse strand
Band p21.32
Transcripts
ENST00000336984 ENSP00000337463
ENST00000375107 ENSP00000364248
ENST00000375104 ENSP00000364245
ENST00000395499 ENSP00000378877
ENST00000395497 ENSP00000378875
ENST00000395496 ENSP00000378874
ENST00000490711
ENST00000476663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0006112 energy reserve metabolic process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0008152 metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0031325 positive regulation of cellular metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034254
View Gene Order
ENSBTAG00000004442
Not yet available
Pathways
NETPATH
REACTOME
REACT_120906
Synthesis of PA pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_2122
ChREBP activates metabolic gene expression pathway
REACT_1505
Integration of energy metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00561
Glycerolipid metabolism pathway
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q99943
TrEMBL A0A024RCV5 Q71VH6 Q9HBM8
UniProt Splice Variant
Entrez Gene 10554
UniGene Hs.409230
RefSeq NM_006411 NM_032741 XM_005248805 XM_005248806
HUGO HGNC:324
OMIM 603099
CCDS CCDS4744
HPRD
IMGT
EMBL AF007145 AF218034 AK315950 AL662828 AL662884 AL845464 BC002402 BC003007 BC004310 BC090849 BX284686 BX927239 CH471081 CR812478 CR933878 U56417 U75971 U89336 Y09565
GenPept AAB47493 AAB58775 AAB96378 AAC19153 AAG17276 AAH02402 AAH03007 AAH04310 AAH90849 BAH14321 CAA70758 CAI17430 CAI18347 CAI41807 CAM26221 CAQ06593 CAQ09622 CAQ10697 EAX03600 EAX03601 EAX03602 EAX03603 EAX03604 EAX03605
RNA Seq Atlas 10554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca