InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MADD

Summary

InnateDB Protein

IDBP-239665.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MADD

Protein Name

MAP-kinase activating death domain

Synonyms

DENN; IG20; RAB3GEP;

Species

Homo sapiens

Ensembl Protein

ENSP00000378745

InnateDB Gene

IDBG-42977 (MADD)

Protein Structure

UniProt Annotation

Function

Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. {ECO:0000269PubMed:11577081, ECO:0000269PubMed:14716293, ECO:0000269PubMed:14735464, ECO:0000269PubMed:15007167, ECO:0000269PubMed:20937701, ECO:0000269PubMed:9115275}.

Subcellular Localization

Membrane {ECO:0000269PubMed:8988362}. Cytoplasm {ECO:0000269PubMed:8988362}.

Disease Associations

Tissue Specificity

Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines. {ECO:0000269PubMed:14716293, ECO:0000269PubMed:8988362, ECO:0000269PubMed:9796103}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005123	death receptor binding
GO:0005515	protein binding
GO:0017112	Rab guanyl-nucleotide exchange factor activity
GO:0030295	protein kinase activator activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007166	cell surface receptor signaling pathway
GO:0032483	regulation of Rab protein signal transduction
GO:0032851	positive regulation of Rab GTPase activity
GO:0042981	regulation of apoptotic process
GO:0051726	regulation of cell cycle
GO:0097194	execution phase of apoptosis
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001236	regulation of extrinsic apoptotic signaling pathway