Version 5.4
Homo sapiens Gene: MADD
Summary
InnateDB Gene IDBG-42977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MADD
Gene Name MAP-kinase activating death domain
Synonyms DENN; IG20; RAB3GEP
Species Homo sapiens
Ensembl Gene ENSG00000110514
Encoded Proteins
IDBP-42979
MAP-kinase activating death domain
IDBP-42981
MAP-kinase activating death domain
IDBP-42983
MAP-kinase activating death domain
IDBP-239661
MAP-kinase activating death domain
IDBP-239665
MAP-kinase activating death domain
IDBP-293051
MAP-kinase activating death domain
IDBP-293055
MAP-kinase activating death domain
IDBP-293050
MAP-kinase activating death domain
IDBP-293035
MAP-kinase activating death domain
IDBP-293046
MAP-kinase activating death domain
IDBP-373355
MAP-kinase activating death domain
IDBP-373413
MAP-kinase activating death domain
IDBP-373417
MAP-kinase activating death domain
IDBP-373438
MAP-kinase activating death domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47269161-47330031
Strand Forward strand
Band p11.2
Transcripts
ENST00000342922 ENSP00000343902
ENST00000311027 ENSP00000310933
ENST00000349238 ENSP00000304505
ENST00000395344 ENSP00000378753
ENST00000395336 ENSP00000378745
ENST00000402799 ENSP00000385585
ENST00000407859 ENSP00000384204
ENST00000402192 ENSP00000384287
ENST00000406482 ENSP00000384435
ENST00000405573 ENSP00000384483
ENST00000453571 ENSP00000388255
ENST00000428807 ENSP00000398167
ENST00000444117 ENSP00000413116
ENST00000422579 ENSP00000402364
ENST00000489415
ENST00000460452
ENST00000494403
ENST00000469699
ENST00000534808
ENST00000526603
ENST00000524530
ENST00000524686
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0030295 protein kinase activator activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0007166 cell surface receptor signaling pathway
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
GO:0042981 regulation of apoptotic process
GO:0051726 regulation of cell cycle
GO:0097194 execution phase of apoptosis
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040687
View Gene Order
ENSBTAG00000021700
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
tnfpathway
TNF receptor signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.82548
RefSeq NM_001135943 NM_001135944 NM_003682 NM_130470 NM_130471 NM_130472 NM_130473 NM_130474 NM_130475 NM_130476 XM_005253188 XM_005253189 XM_005253190 XM_005253195 XM_005253196 XM_005253197 XM_005253199 XM_005253200 XM_005253201 XM_005253203 XM_005253204 XM_005253205 XM_005253206 XM_006718361
HUGO
OMIM
CCDS CCDS41642 CCDS44586 CCDS44587 CCDS44588 CCDS44589 CCDS44590 CCDS7930 CCDS7931 CCDS7932
HPRD 04664
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca