InnateDB Protein
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IDBP-239685.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPN
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Protein Name
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sialophorin
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Synonyms
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CD43; GALGP; GPL115; LSN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378787
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InnateDB Gene
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IDBG-24512 (SPN)
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Protein Structure
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Function |
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004888
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transmembrane signaling receptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P16150
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PhosphoSite |
PhosphoSite-P16150
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TrEMBL |
C9JUK7
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UniProt Splice Variant |
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Entrez Gene |
6693
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UniGene |
Hs.632188
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RefSeq |
NP_001025459
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HUGO |
HGNC:11249
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OMIM |
182160
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CCDS |
CCDS10650
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HPRD |
06770
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IMGT |
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EMBL |
AC009086
AK292626
AK313750
BC012350
CH471238
J04168
J04536
M61827
X52075
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GenPept |
AAA51949
AAA59510
AAB59540
AAH12350
BAF85315
BAG36490
CAA36294
EAW80015
EAW80016
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