InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPN

Summary

InnateDB Gene

IDBG-24512.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPN

Gene Name

sialophorin

Synonyms

CD43; GALGP; GPL115; LSN

Species

Homo sapiens

Ensembl Gene

ENSG00000197471

Encoded Proteins

IDBP-24514

sialophorin

IDBP-239685

sialophorin

IDBP-374596

sialophorin

IDBP-746280

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:29662979-29670876

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000360121	ENSP00000353238
ENST00000395389	ENSP00000378787
ENST00000436527	ENSP00000412907
ENST00000563039	ENSP00000455266

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0001562	response to protozoan
GO:0001808	negative regulation of type IV hypersensitivity
GO:0001934	positive regulation of protein phosphorylation
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007162	negative regulation of cell adhesion
GO:0007163	establishment or maintenance of cell polarity
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007596	blood coagulation
GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0042742	defense response to bacterium
GO:0045060	negative thymic T cell selection
GO:0050688	regulation of defense response to virus
GO:0050776	regulation of immune response
GO:0050868	negative regulation of T cell activation
GO:0050900	leukocyte migration
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001931	uropod
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000051457

View Gene Order

ENSBTAG00000026326

Not yet available

Pathways

NETPATH

REACTOME

REACT_12560

Basigin interactions pathway

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_604

Hemostasis pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Cross-References

SwissProt

P16150

TrEMBL

A0A024R629 C9JUK7

UniProt Splice Variant

Entrez Gene

6693

UniGene

Hs.595610 Hs.632188

RefSeq

NM_001030288 NM_003123 XM_005276513

HUGO

HGNC:11249

OMIM

182160

CCDS

CCDS10650

HPRD

IMGT

EMBL

AC009086 AK292626 AK313750 BC012350 CH471238 J04168 J04536 M61827 X52075

GenPept

AAA51949 AAA59510 AAB59540 AAH12350 BAF85315 BAG36490 CAA36294 EAW80015 EAW80016

RNA Seq Atlas

101929889 6693