InnateDB Protein
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IDBP-239704.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP1CB
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Protein Name
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protein phosphatase 1, catalytic subunit, beta isozyme
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Synonyms
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HEL-S-80p; PP-1B; PP1B; PP1beta; PPP1CD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378769
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InnateDB Gene
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IDBG-239700 (PPP1CB)
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Protein Structure
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Function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. {ECO:0000269PubMed:20516061, ECO:0000269PubMed:21712997}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11739654}. Nucleus {ECO:0000269PubMed:11739654}. Nucleus, nucleoplasm {ECO:0000269PubMed:11739654}. Nucleus, nucleolus {ECO:0000269PubMed:11739654}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004843
Calcineurin-like phosphoesterase domain, apaH type
IPR006186
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052
Metallo-dependent phosphatase-like
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PFAM |
PF00149
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PRINTS |
PR00114
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PIRSF |
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SMART |
SM00156
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TIGRFAMs |
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Modification |
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SwissProt |
P62140
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PhosphoSite |
PhosphoSite-P62140
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TrEMBL |
V9HW04
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UniProt Splice Variant |
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Entrez Gene |
5500
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UniGene |
Hs.702907
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RefSeq |
NP_002700
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HUGO |
HGNC:9282
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OMIM |
600590
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CCDS |
CCDS33169
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HPRD |
11792
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IMGT |
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EMBL |
AB505431
AC097724
AF092905
AK295957
AK312329
BC002697
BC012045
BT019744
BX647970
CH471053
CR542263
CR542285
EU668339
U10998
U10999
U11000
U11001
U11002
U11003
U11004
U11005
X80910
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GenPept |
AAA85093
AAF01137
AAH02697
AAH12045
AAV38549
AAY24124
ACF94492
BAG35251
BAG58737
BAH69083
CAA56870
CAG47059
CAG47080
EAX00527
EAX00528
EAX00529
EAX00530
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