InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP1CB

Summary

InnateDB Gene

IDBG-239700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1CB

Gene Name

protein phosphatase 1, catalytic subunit, beta isozyme

Synonyms

HEL-S-80p; PP-1B; PP1B; PP1beta; PPP1CD

Species

Homo sapiens

Ensembl Gene

ENSG00000213639

Encoded Proteins

IDBP-41360

protein phosphatase 1, catalytic subunit, beta isozyme

IDBP-41362

protein phosphatase 1, catalytic subunit, beta isozyme

IDBP-239704

protein phosphatase 1, catalytic subunit, beta isozyme

IDBP-370856

protein phosphatase 1, catalytic subunit, beta isozyme

IDBP-370859

protein phosphatase 1, catalytic subunit, beta isozyme

IDBP-370861

protein phosphatase 1, catalytic subunit, beta isozyme

IDBP-370866

protein phosphatase 1, catalytic subunit, beta isozyme

IDBP-370876

protein phosphatase 1, catalytic subunit, beta isozyme

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:28751640-28802940

Strand

Forward strand

Band

p23.2

Transcripts

ENST00000358506	ENSP00000351298
ENST00000296122	ENSP00000296122
ENST00000395366	ENSP00000378769
ENST00000455580	ENSP00000390715
ENST00000420282	ENSP00000398839
ENST00000441461	ENSP00000414918
ENST00000427786	ENSP00000394589
ENST00000418910	ENSP00000388056
ENST00000464273

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	91 [view]
Protein-Protein	86 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0017018	myosin phosphatase activity
GO:0019901	protein kinase binding
GO:0046872	metal ion binding
GO:0050115	myosin-light-chain-phosphatase activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0005977	glycogen metabolic process
GO:0005979	regulation of glycogen biosynthetic process
GO:0005981	regulation of glycogen catabolic process
GO:0006470	protein dephosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008152	metabolic process
GO:0019433	triglyceride catabolic process
GO:0030155	regulation of cell adhesion
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0044281	small molecule metabolic process
GO:0051301	cell division

Cellular Component

GO:0000164	protein phosphatase type 1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0042587	glycogen granule
GO:0070062	extracellular vesicular exosome
GO:0070688	MLL5-L complex
GO:0072357	PTW/PP1 phosphatase complex