InnateDB Protein
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IDBP-239737.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MVP
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Protein Name
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major vault protein
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Synonyms
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LRP; VAULT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378760
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InnateDB Gene
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IDBG-24815 (MVP)
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Protein Structure
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Function |
Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269PubMed:15133037, ECO:0000269PubMed:16418217, ECO:0000269PubMed:16441665}.
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Subcellular Localization |
Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
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Disease Associations |
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Tissue Specificity |
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
79
[view]
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Protein-Protein |
77
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002499
Major vault protein, N-terminal
IPR021870
Shoulder domain
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PFAM |
PF01505
PF11978
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14764
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PhosphoSite |
PhosphoSite-Q14764
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TrEMBL |
X5D2M8
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UniProt Splice Variant |
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Entrez Gene |
9961
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UniGene |
Hs.632177
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RefSeq |
NP_059447
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HUGO |
HGNC:7531
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OMIM |
605088
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CCDS |
CCDS10656
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HPRD |
05475
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IMGT |
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EMBL |
AC009133
AC120114
AJ238512
AJ238514
AJ238516
AJ238518
AJ238519
AJ291365
AJ291366
AJ291367
BC015623
CH471238
KJ534884
X79882
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GenPept |
AAH15623
AHW56524
CAA56256
CAB55354
CAB55355
CAC35313
CAC35314
CAC35316
EAW79981
EAW79982
EAW79983
EAW79984
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