Version 5.4
Homo sapiens Protein: OSBPL5
Summary
InnateDB Protein IDBP-23978.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL5
Protein Name oxysterol binding protein-like 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000374639
InnateDB Gene IDBG-23966 (OSBPL5)
Protein Structure
UniProt Annotation
Function May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. {ECO:0000269PubMed:21220512}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:21220512}; Single-pass membrane protein {ECO:0000269PubMed:21220512}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:12504849, ECO:0000269PubMed:21220512}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008142 oxysterol binding
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
GO:0006893 Golgi to plasma membrane transport
GO:0008203 cholesterol metabolic process
GO:0030301 cholesterol transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000648 Oxysterol-binding protein
PFAM PF01237
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0X9
PhosphoSite PhosphoSite-Q9H0X9
TrEMBL H0YCD7
UniProt Splice Variant
Entrez Gene 114879
UniGene Hs.436166
RefSeq NP_663613
HUGO HGNC:16392
OMIM 606733
CCDS CCDS31343
HPRD 09475
IMGT
EMBL AB040967 AB074006 AC108448 AF331964 AF392453 AF410430 AK056510 AL136918 BC032646 BC039579 CH471158
GenPept AAG53417 AAH32646 AAH39579 AAK98617 AAL40666 BAA96058 BAB85686 BAG51735 CAB66852 EAX02542 EAX02543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca