InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNASE2

Summary

InnateDB Protein

IDBP-2398.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASE2

Protein Name

ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)

Synonyms

EDN; RAF3; RNS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000303276

InnateDB Gene

IDBG-2396 (RNASE2)

Protein Structure

UniProt Annotation

Function

This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. {ECO:0000269PubMed:12578357, ECO:0000269PubMed:3458170}.

Subcellular Localization

Lysosome {ECO:0000305}. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.

Disease Associations

Tissue Specificity

Liver, lung, spleen, leukocytes and body fluids.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004522	pancreatic ribonuclease activity
GO:0004540	ribonuclease activity

Biological Process

GO:0006401	RNA catabolic process
GO:0006935	chemotaxis
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic