Version 5.4
Homo sapiens Protein: HERC4
Summary
InnateDB Protein IDBP-240016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC4
Protein Name hect domain and RLD 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378624
InnateDB Gene IDBG-75877 (HERC4)
Protein Structure
UniProt Annotation
Function Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:15676274}. Note=shows a punctate cytoplasmic distribution.
Disease Associations
Tissue Specificity Expressed in brain and testis and detected in heart and placenta. {ECO:0000269PubMed:15676274}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
Biological Process
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000408 Regulator of chromosome condensation, RCC1
IPR000569 HECT
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFAM PF00415
PF00632
PRINTS PR00633
PIRSF
SMART SM00119
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5GLZ8
PhosphoSite PhosphoSite-Q5GLZ8
TrEMBL D6RFK9
UniProt Splice Variant
Entrez Gene 26091
UniGene Hs.604443
RefSeq NP_071362
HUGO HGNC:24521
OMIM 609248
CCDS CCDS41533
HPRD 13646
IMGT
EMBL AB046813 AC024258 AL133551 AL356741 AY221963 AY650032 AY650033 AY650034 BC039600
GenPept AAH39600 AAO65480 AAV66578 AAV66579 AAV66580 BAB13419 CAH74148 CAI16032

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca