Version 5.4
Homo sapiens Gene: HERC4
Summary
InnateDB Gene IDBG-75877.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC4
Gene Name HECT and RLD domain containing E3 ubiquitin protein ligase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148634
Encoded Proteins
IDBP-75879
hect domain and RLD 4
IDBP-75881
hect domain and RLD 4
IDBP-240016
hect domain and RLD 4
IDBP-377703
hect domain and RLD 4
IDBP-377708
hect domain and RLD 4
IDBP-481131
hect domain and RLD 4
IDBP-475290
hect domain and RLD 4
IDBP-477814
hect domain and RLD 4
IDBP-484338
hect domain and RLD 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:67921899-68075348
Strand Reverse strand
Band q21.3
Transcripts
ENST00000373700 ENSP00000362804
ENST00000277817 ENSP00000277817
ENST00000395198 ENSP00000378624
ENST00000395185
ENST00000412272 ENSP00000416504
ENST00000427635 ENSP00000406171
ENST00000473533 ENSP00000423671
ENST00000480158
ENST00000460168
ENST00000463478
ENST00000513996 ENSP00000427191
ENST00000505760
ENST00000492996 ENSP00000422383
ENST00000506515 ENSP00000426563
ENST00000515753
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
Biological Process
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020064
View Gene Order
ENSBTAG00000014029
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.51891 Hs.604443
RefSeq NM_001278185 NM_001278186 NM_001278187 NM_015601 NM_022079 XM_006717751 XM_006717753
HUGO
OMIM
CCDS CCDS41533 CCDS60541 CCDS60542 CCDS7274
HPRD 13646
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca