InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EEF1D

Summary

InnateDB Protein

IDBP-240185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF1D

Protein Name

eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

Synonyms

EF-1D; EF1D; FP1047;

Species

Homo sapiens

Ensembl Protein

ENSP00000378551

InnateDB Gene

IDBG-38640 (EEF1D)

Protein Structure

UniProt Annotation

Function

Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).

Subcellular Localization

Isoform 2: Nucleus {ECO:0000269PubMed:21597468}.

Disease Associations

Tissue Specificity

Isoform 2 is specifically expressed in brain, cerebellum and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	84 [view]
Protein-Protein	84 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003746	translation elongation factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008135	translation factor activity, nucleic acid binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006412	translation
GO:0006414	translational elongation
GO:0007165	signal transduction
GO:0010467	gene expression
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005853	eukaryotic translation elongation factor 1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR014038 Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange
IPR018940 Elongation factor 1 beta central acidic region, eukaryote

PFAM

PF00736
PF10587

PRINTS

PIRSF

SMART

SM00888

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29692