InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPM1A

Summary

InnateDB Protein

IDBP-240283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPM1A

Protein Name

protein phosphatase, Mg2+/Mn2+ dependent, 1A

Synonyms

PP2C-ALPHA; PP2CA; PP2Calpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000378514

InnateDB Gene

IDBG-8210 (PPM1A)

Protein Structure

UniProt Annotation

Function

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269PubMed:16751101, ECO:0000269PubMed:18930133}.

Subcellular Localization

Nucleus. Cytoplasm, cytosol. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0030145	manganese ion binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046872	metal ion binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006470	protein dephosphorylation
GO:0006499	N-terminal protein myristoylation
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0010467	gene expression
GO:0010991	negative regulation of SMAD protein complex assembly
GO:0016055	Wnt signaling pathway
GO:0016311	dephosphorylation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035970	peptidyl-threonine dephosphorylation
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893	positive regulation of transcription, DNA-templated