InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRM2

Summary

InnateDB Protein

IDBP-240345.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM2

Protein Name

glutamate receptor, metabotropic 2

Synonyms

GLUR2; GPRC1B; mGlu2; MGLUR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000378492

InnateDB Gene

IDBG-37548 (GRM2)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269PubMed:18297054, ECO:0000269PubMed:22300836, ECO:0000269PubMed:23129762, ECO:0000269PubMed:7620613}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. {ECO:0000269PubMed:18297054}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001641	group II metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0014047	glutamate secretion
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001234 GPCR, family 3, metabotropic glutamate receptor 3
IPR001458 GPCR, family 3, metabotropic glutamate receptor 2
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR00593
PR00248
PR01053
PR01052

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14416