InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRM2

Summary

InnateDB Gene

IDBG-37548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM2

Gene Name

glutamate receptor, metabotropic 2

Synonyms

GLUR2; GPRC1B; mGlu2; MGLUR2

Species

Homo sapiens

Ensembl Gene

ENSG00000164082

Encoded Proteins

IDBP-37550

glutamate receptor, metabotropic 2

IDBP-240345

glutamate receptor, metabotropic 2

IDBP-378795

glutamate receptor, metabotropic 2

IDBP-378798

glutamate receptor, metabotropic 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:51707070-51718613

Strand

Forward strand

Band

p21.2

Transcripts

ENST00000296479	ENSP00000296479
ENST00000395052	ENSP00000378492
ENST00000419928	ENSP00000404797
ENST00000442933	ENSP00000408906
ENST00000475478
ENST00000464585
ENST00000496661
ENST00000477330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001641	group II metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0014047	glutamate secretion
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0043005	neuron projection

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023192

View Gene Order

ENSBTAG00000001067

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_18319

Class C/3 (Metabotropic glutamate/pheromone receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000839 XM_006713121

HUGO

OMIM

CCDS

CCDS2834

HPRD

04977

IMGT

EMBL

GenPept

RNA Seq Atlas