InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASCC1

Summary

InnateDB Protein

IDBP-240606.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASCC1

Protein Name

activating signal cointegrator 1 complex subunit 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378373

InnateDB Gene

IDBG-77835 (ASCC1)

Protein Structure

UniProt Annotation

Function

Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. {ECO:0000269PubMed:19074642}.

Subcellular Localization

Cytoplasm.

Disease Associations

Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269PubMed:21791690}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0003824	catalytic activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR004088 K Homology domain, type 1
IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase
IPR009210 Predicted eukaryotic LigT
IPR019510 Protein kinase A anchor protein, nuclear localisation signal domain

PFAM

PF00013
PF13014
PF10469

PRINTS

PIRSF

PIRSF027019

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N9N2