Version 5.4
Homo sapiens Gene: ASCC1
Summary
InnateDB Gene IDBG-77835.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASCC1
Gene Name activating signal cointegrator 1 complex subunit 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138303
Encoded Proteins
IDBP-77837
activating signal cointegrator 1 complex subunit 1
IDBP-77839
activating signal cointegrator 1 complex subunit 1
IDBP-77843
activating signal cointegrator 1 complex subunit 1
IDBP-240604
activating signal cointegrator 1 complex subunit 1
IDBP-240606
activating signal cointegrator 1 complex subunit 1
IDBP-591472
activating signal cointegrator 1 complex subunit 1
IDBP-598594
activating signal cointegrator 1 complex subunit 1
IDBP-588590
activating signal cointegrator 1 complex subunit 1
IDBP-585408
activating signal cointegrator 1 complex subunit 1
IDBP-600483
activating signal cointegrator 1 complex subunit 1
IDBP-588104
activating signal cointegrator 1 complex subunit 1
IDBP-592642
activating signal cointegrator 1 complex subunit 1
IDBP-587171
activating signal cointegrator 1 complex subunit 1
IDBP-601125
activating signal cointegrator 1 complex subunit 1
IDBP-597942
activating signal cointegrator 1 complex subunit 1
IDBP-593560
activating signal cointegrator 1 complex subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:72096032-72217134
Strand Reverse strand
Band q22.1
Transcripts
ENST00000342444 ENSP00000339404
ENST00000317168 ENSP00000320810
ENST00000317126 ENSP00000320461
ENST00000394919 ENSP00000378377
ENST00000394915 ENSP00000378373
ENST00000486689 ENSP00000431299
ENST00000461369 ENSP00000435191
ENST00000492502
ENST00000534259
ENST00000530394 ENSP00000436409
ENST00000525286 ENSP00000435147
ENST00000526801
ENST00000531048 ENSP00000436098
ENST00000530461 ENSP00000431255
ENST00000527593 ENSP00000432418
ENST00000524829 ENSP00000431573
ENST00000532011 ENSP00000434468
ENST00000526751 ENSP00000431419
ENST00000533958 ENSP00000431746
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003824 catalytic activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008152 metabolic process
Cellular Component
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044475
View Gene Order
ENSBTAG00000000392
Not yet available
Cross-References
SwissProt
TrEMBL E9PM82
UniProt Splice Variant
Entrez Gene 51008
UniGene Hs.500007 Hs.607176
RefSeq NM_001198798 NM_001198799 NM_001198800 XM_005269878 XM_006717873 XM_006717874
HUGO HGNC:24268
OMIM 614215
CCDS CCDS31219 CCDS55713
HPRD
IMGT
EMBL AC022392 AL607035
GenPept
RNA Seq Atlas 51008

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca