InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF16

Summary

InnateDB Protein

IDBP-240634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF16

Protein Name

zinc finger protein 16

Synonyms

HZF1; KOX9;

Species

Homo sapiens

Ensembl Protein

ENSP00000378369

InnateDB Gene

IDBG-41817 (ZNF16)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis. {ECO:0000269PubMed:16628192, ECO:0000269PubMed:19763908, ECO:0000269PubMed:21874239}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16628192}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:16628192}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0008284	positive regulation of cell proliferation
GO:0033674	positive regulation of kinase activity
GO:0043066	negative regulation of apoptotic process
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0051301	cell division
GO:0051781	positive regulation of cell division
GO:0072707	cellular response to sodium dodecyl sulfate
GO:1901989	positive regulation of cell cycle phase transition