InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAK

Summary

InnateDB Protein

IDBP-240650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAK

Protein Name

dihydroxyacetone kinase 2 homolog (S. cerevisiae)

Synonyms

NET45;

Species

Homo sapiens

Ensembl Protein

ENSP00000378360

InnateDB Gene

IDBG-50063 (DAK)

Protein Structure

UniProt Annotation

Function

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. {ECO:0000269PubMed:16289032, ECO:0000269PubMed:4688871}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in erythrocytes (at protein level). {ECO:0000269PubMed:4688871}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004371	glycerone kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0034012	FAD-AMP lyase (cyclizing) activity
GO:0046872	metal ion binding
GO:0050354	triokinase activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0016310	phosphorylation
GO:0044262	cellular carbohydrate metabolic process
GO:0045087	innate immune response
GO:0045088	regulation of innate immune response
GO:0046835	carbohydrate phosphorylation