InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPSF7

Summary

InnateDB Protein

IDBP-240674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPSF7

Protein Name

cleavage and polyadenylation specific factor 7, 59kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378352

InnateDB Gene

IDBG-50138 (CPSF7)

Protein Structure

UniProt Annotation

Function

Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Binds to cleavage and polyadenylation RNA substrates. {ECO:0000269PubMed:8626397}.

Subcellular Localization

Nucleus {ECO:0000305PubMed:20695905}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0051262	protein tetramerization