InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZP3

Summary

InnateDB Protein

IDBP-240733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZP3

Protein Name

zona pellucida glycoprotein 3 (sperm receptor)

Synonyms

Zp-3; ZP3A; ZP3B; ZPC;

Species

Homo sapiens

Ensembl Protein

ENSP00000378326

InnateDB Gene

IDBG-23247 (ZP3)

Protein Structure

UniProt Annotation

Function

The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Subcellular Localization

Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Oocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005384	manganese ion transmembrane transporter activity
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0030246	carbohydrate binding
GO:0032190	acrosin binding

Biological Process

GO:0001809	positive regulation of type IV hypersensitivity
GO:0001825	blastocyst formation
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0002687	positive regulation of leukocyte migration
GO:0002922	positive regulation of humoral immune response
GO:0006828	manganese ion transport
GO:0006886	intracellular protein transport
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0032504	multicellular organism reproduction
GO:0032729	positive regulation of interferon-gamma production
GO:0032753	positive regulation of interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0035803	egg coat formation
GO:0042102	positive regulation of T cell proliferation
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048599	oocyte development
GO:0050729	positive regulation of inflammatory response
GO:0051897	positive regulation of protein kinase B signaling
GO:0070528	protein kinase C signaling
GO:0070588	calcium ion transmembrane transport
GO:0071421	manganese ion transmembrane transport
GO:0090280	positive regulation of calcium ion import
GO:2000344	positive regulation of acrosome reaction
GO:2000360	negative regulation of binding of sperm to zona pellucida
GO:2000368	positive regulation of acrosomal vesicle exocytosis
GO:2000386	positive regulation of ovarian follicle development
GO:2000388	positive regulation of antral ovarian follicle growth

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002081	outer acrosomal membrane
GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix
GO:0048471	perinuclear region of cytoplasm