InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP3CB

Summary

InnateDB Protein

IDBP-240785.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP3CB

Protein Name

protein phosphatase 3, catalytic subunit, beta isozyme

Synonyms

CALNA2; CALNB; CNA2; PP2Bbeta;

Species

Homo sapiens

Ensembl Protein

ENSP00000378305

InnateDB Gene

IDBG-78455 (PPP3CB)

Protein Structure

UniProt Annotation

Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008144	drug binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0030346	protein phosphatase 2B binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0007165	signal transduction
GO:0007612	learning
GO:0007613	memory
GO:0016311	dephosphorylation
GO:0017156	calcium ion-dependent exocytosis
GO:0035176	social behavior
GO:0035690	cellular response to drug
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042098	T cell proliferation
GO:0042110	T cell activation
GO:0045087	innate immune response
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048167	regulation of synaptic plasticity
GO:0048675	axon extension
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005955	calcineurin complex

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt