InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYLK3

Summary

InnateDB Protein

IDBP-240844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYLK3

Protein Name

myosin light chain kinase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378288

InnateDB Gene

IDBG-29378 (MYLK3)

Protein Structure

UniProt Annotation

Function

Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Restricted to heart. {ECO:0000269PubMed:17885681}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004687	myosin light chain kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0002528	regulation of vascular permeability involved in acute inflammatory response
GO:0006468	protein phosphorylation
GO:0045214	sarcomere organization
GO:0048769	sarcomerogenesis
GO:0055003	cardiac myofibril assembly
GO:0060298	positive regulation of sarcomere organization
GO:0071347	cellular response to interleukin-1

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015629	actin cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt