Version 5.4
Homo sapiens Gene: MYLK3
Summary
InnateDB Gene IDBG-29378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYLK3
Gene Name myosin light chain kinase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140795
Encoded Proteins
IDBP-240844
myosin light chain kinase 3
IDBP-591765
myosin light chain kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:46706979-46790407
Strand Reverse strand
Band q11.2
Transcripts
ENST00000394809 ENSP00000378288
ENST00000536476 ENSP00000439297
ENST00000564731
ENST00000565182
ENST00000569844
ENST00000562104
ENST00000569810
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004687 myosin light chain kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0002528 regulation of vascular permeability involved in acute inflammatory response
GO:0006468 protein phosphorylation
GO:0045214 sarcomere organization
GO:0048769 sarcomerogenesis
GO:0055003 cardiac myofibril assembly
GO:0060298 positive regulation of sarcomere organization
GO:0071347 cellular response to interleukin-1
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031698
View Gene Order
ENSBTAG00000014818
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04510
Focal adhesion pathway
hsa04020
Calcium signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt Q32MK0
TrEMBL
UniProt Splice Variant
Entrez Gene 91807
UniGene Hs.130465
RefSeq NM_182493 XM_006721333 XM_006721334
HUGO HGNC:29826
OMIM 612147
CCDS CCDS10723
HPRD
IMGT
EMBL AB451455 AC007225 AJ247087 AK299443 BC109097
GenPept AAI09098 BAG70269 BAH13034 CAC42766
RNA Seq Atlas 91807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca