Homo sapiens Protein: CLCA1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-241026.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CLCA1 | ||||||||||||||||||
Protein Name | chloride channel accessory 1 | ||||||||||||||||||
Synonyms | CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1; hCLCA1; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000378200 | ||||||||||||||||||
InnateDB Gene | IDBG-100081 (CLCA1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269PubMed:11445004, ECO:0000269PubMed:11842292, ECO:0000269PubMed:11956057, ECO:0000269PubMed:9828122}. | ||||||||||||||||||
Subcellular Localization | Secreted, extracellular space {ECO:0000269PubMed:15919655}. Cell membrane {ECO:0000269PubMed:15919655}; Peripheral membrane protein {ECO:0000269PubMed:15919655}; Extracellular side {ECO:0000269PubMed:15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in. {ECO:0000269PubMed:10437792, ECO:0000269PubMed:11842292, ECO:0000269PubMed:11956057, ECO:0000269PubMed:16012037, ECO:0000269PubMed:9828122}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR002035
von Willebrand factor, type A IPR003961 Fibronectin, type III IPR004727 Calcium-activated chloride channel protein IPR013642 Chloride channel calcium-activated IPR015394 Domain of unknown function DUF1973 |
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PFAM |
PF00092
PF00041 PF01108 PF08434 PF09315 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00327
SM00060 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | A8K7I4 | ||||||||||||||||||
PhosphoSite | PhosphoSite-A8K7I4 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 1179 | ||||||||||||||||||
UniGene | Hs.606218 | ||||||||||||||||||
RefSeq | NP_001276 | ||||||||||||||||||
HUGO | HGNC:2015 | ||||||||||||||||||
OMIM | 603906 | ||||||||||||||||||
CCDS | CCDS709 | ||||||||||||||||||
HPRD | 04880 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF039400 AF039401 AF127036 AK291999 AK314375 AL122002 CH471097 | ||||||||||||||||||
GenPept | AAC95428 AAC95429 AAD25487 BAF84688 BAG37002 CAI22169 EAW73186 | ||||||||||||||||||