InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RTN4

Summary

InnateDB Protein

IDBP-241179.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RTN4

Protein Name

reticulon 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378109

InnateDB Gene

IDBG-52161 (RTN4)

Protein Structure

UniProt Annotation

Function

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. {ECO:0000250, ECO:0000269PubMed:10667797, ECO:0000269PubMed:11201742, ECO:0000269PubMed:16965550}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.

Disease Associations

Tissue Specificity

Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis- specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	60 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006915	apoptotic process
GO:0007413	axonal fasciculation
GO:0021801	cerebral cortex radial glia guided migration
GO:0030308	negative regulation of cell growth
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0042981	regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis
GO:0071786	endoplasmic reticulum tubular network organization
GO:2000172	regulation of branching morphogenesis of a nerve

Cellular Component

GO:0005622	intracellular
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome