Version 5.4
Homo sapiens Gene: RTN4
Summary
InnateDB Gene IDBG-52161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN4
Gene Name reticulon 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115310
Encoded Proteins
IDBP-52163
reticulon 4
IDBP-52165
reticulon 4
IDBP-52167
reticulon 4
IDBP-52171
reticulon 4
IDBP-241179
reticulon 4
IDBP-241181
reticulon 4
IDBP-293341
reticulon 4
IDBP-293340
reticulon 4
IDBP-293333
reticulon 4
IDBP-376168
reticulon 4
IDBP-376170
reticulon 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:54972187-55112621
Strand Reverse strand
Band p16.1
Transcripts
ENST00000357376 ENSP00000349944
ENST00000337526 ENSP00000337838
ENST00000357732 ENSP00000350365
ENST00000317610 ENSP00000322147
ENST00000394611 ENSP00000378109
ENST00000394609 ENSP00000378107
ENST00000402434 ENSP00000384825
ENST00000405240 ENSP00000384471
ENST00000404909 ENSP00000385650
ENST00000438462 ENSP00000397808
ENST00000427710 ENSP00000411628
ENST00000486085
ENST00000491592
ENST00000485749
ENST00000461004
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0007399 nervous system development
GO:0007413 axonal fasciculation
GO:0021801 cerebral cortex radial glia guided migration
GO:0030308 negative regulation of cell growth
GO:0030334 regulation of cell migration
GO:0030517 negative regulation of axon extension
GO:0042981 regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0051960 regulation of nervous system development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0071786 endoplasmic reticulum tubular network organization
GO:2000172 regulation of branching morphogenesis of a nerve
Cellular Component
GO:0005622 intracellular
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020458
View Gene Order
ENSBTAG00000011104
Not yet available
Pathways
NETPATH
REACTOME
REACT_13815
Axonal growth inhibition (RHOA activation) pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9NQC3
TrEMBL C9J685 F8W914 Q53R94 Q53RF4 Q53SY1
UniProt Splice Variant
Entrez Gene 57142
UniGene Hs.637850 Hs.707916 Hs.738763 Hs.743923
RefSeq NM_007008 NM_020532 NM_153828 NM_207520 NM_207521 XM_005264434
HUGO HGNC:14085
OMIM 604475
CCDS CCDS1851 CCDS1852 CCDS42683 CCDS42684 CCDS42685
HPRD
IMGT
EMBL AB015639 AB020693 AB040462 AB040463 AC013414 AC092461 AC093165 AF063601 AF077050 AF087901 AF125103 AF132047 AF132048 AF148537 AF148538 AF177332 AF320999 AF333336 AJ251383 AJ251384 AJ251385 AY102276 AY102277 AY102278 AY102279 AY102285 AY123245 AY123246 AY123247 AY123248 AY123249 AY123250 BC001035 BC007109 BC010737 BC012619 BC014366 BC016165 BC026788 BC068991 BC150182 BC152425 BC152555 CH471053
GenPept AAD27783 AAD31021 AAD31022 AAD39920 AAG12176 AAG12177 AAG12205 AAG17976 AAG40878 AAG43160 AAH01035 AAH07109 AAH10737 AAH12619 AAH14366 AAH16165 AAH26788 AAH68991 AAI50183 AAI52426 AAI52556 AAK20831 AAM64240 AAM64241 AAM64242 AAM64243 AAM64244 AAM64245 AAM64246 AAM64247 AAM64248 AAM64249 AAM64250 AAM64251 AAM64252 AAM64253 AAM64254 AAX93116 AAY24029 AAY24239 BAA74909 BAA83712 BAB18927 BAB18928 CAB99248 CAB99249 CAB99250 EAX00115 EAX00116 EAX00117 EAX00118 EAX00119 EAX00121 EAX00122 EAX00123 EAX00124 EAX00125 EAX00127 EAX00130 EAX00132
RNA Seq Atlas 57142

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca