InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAD51D

Summary

InnateDB Protein

IDBP-241284.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD51D

Protein Name

RAD51 homolog D (S. cerevisiae)

Synonyms

BROVCA4; R51H3; RAD51L3; TRAD;

Species

Homo sapiens

Ensembl Protein

ENSP00000378090

InnateDB Gene

IDBG-41136 (RAD51D)

Protein Structure

UniProt Annotation

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single- stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single- stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. {ECO:0000269PubMed:10871607, ECO:0000269PubMed:11751635, ECO:0000269PubMed:11834724, ECO:0000269PubMed:11842113, ECO:0000269PubMed:12975363, ECO:0000269PubMed:15109494, ECO:0000269PubMed:23149936}.

Subcellular Localization

Nucleus {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.

Disease Associations

Breast-ovarian cancer, familial, 4 (BROVCA4) [MIM:614291]: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. {ECO:0000269PubMed:21822267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000400	four-way junction DNA binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0007131	reciprocal meiotic recombination
GO:0042148	strand invasion

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR007694 DNA helicase, DnaB-like, C-terminal
IPR013632 DNA recombination and repair protein Rad51, C-terminal
IPR014774 Circadian clock protein KaiC/DNA repair protein RadA
IPR016467 DNA recombination and repair protein, RecA-like
IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03796
PF08423
PF06745

PRINTS

PIRSF

PIRSF005856

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt