InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAD51D

Summary

InnateDB Gene

IDBG-41136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD51D

Gene Name

RAD51 homolog D (S. cerevisiae)

Synonyms

BROVCA4; R51H3; RAD51L3; TRAD

Species

Homo sapiens

Ensembl Gene

ENSG00000185379

Encoded Proteins

IDBP-41138

RAD51 homolog D (S. cerevisiae)

IDBP-41140

RAD51 homolog D (S. cerevisiae)

IDBP-241284

RAD51 homolog D (S. cerevisiae)

IDBP-760048

IDBP-764633

IDBP-759905

IDBP-764948

IDBP-759146

IDBP-762797

IDBP-762392

IDBP-760906

IDBP-758402

IDBP-762792

IDBP-762300

IDBP-759577

IDBP-758300

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:35092208-35121522

Strand

Reverse strand

Band

q12

Transcripts

ENST00000345365	ENSP00000338790
ENST00000335858	ENSP00000338408
ENST00000394589	ENSP00000378090
ENST00000415064
ENST00000460118	ENSP00000464356
ENST00000589506
ENST00000590016	ENSP00000466399
ENST00000585947
ENST00000592928
ENST00000586186	ENSP00000468273
ENST00000587977	ENSP00000466587
ENST00000588372	ENSP00000468764
ENST00000590631	ENSP00000465033
ENST00000585343	ENSP00000465007
ENST00000586210	ENSP00000465612
ENST00000592577	ENSP00000466839
ENST00000592850	ENSP00000468724
ENST00000587982
ENST00000592430
ENST00000586044	ENSP00000465584
ENST00000585982
ENST00000587405	ENSP00000466478
ENST00000588594	ENSP00000465366

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000400	four-way junction DNA binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0007131	reciprocal meiotic recombination
GO:0042148	strand invasion

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018841

View Gene Order

ENSBTAG00000019082

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa03440

Homologous recombination pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.609571 Hs.612360

RefSeq

NM_001142571 NM_002878 NM_133629

HUGO

OMIM

CCDS

CCDS11287 CCDS11288 CCDS45646

HPRD

04261

IMGT

EMBL

GenPept

RNA Seq Atlas