InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNK4

Summary

InnateDB Protein

IDBP-241432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNK4

Protein Name

potassium channel, subfamily K, member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378033

InnateDB Gene

IDBG-53522 (KCNK4)

Protein Structure

UniProt Annotation

Function

Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003092 Two pore domain potassium channel, TASK family
IPR003280 Two pore domain potassium channel
IPR003976 Two pore domain potassium channel, TREK
IPR008074 Two pore domain potassium channel, TRAAK
IPR013099 Two pore domain potassium channel domain

PFAM

PF07885

PRINTS

PR01095
PR01333
PR01499
PR01691

PIRSF

PIRSF038061

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt