InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITPR2

Summary

InnateDB Protein

IDBP-24162.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITPR2

Protein Name

inositol 1,4,5-trisphosphate receptor, type 2

Synonyms

CFAP48; IP3R2;

Species

Homo sapiens

Ensembl Protein

ENSP00000370744

InnateDB Gene

IDBG-24160 (ITPR2)

Protein Structure

UniProt Annotation

Function

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform Short is found in skeletal muscle and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0015085	calcium ion transmembrane transporter activity
GO:0015278	calcium-release channel activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001666	response to hypoxia
GO:0006112	energy reserve metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0030168	platelet activation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071361	cellular response to ethanol

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031095	platelet dense tubular network membrane
GO:0033017	sarcoplasmic reticulum membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR000699 RIH (RyR and IP3R Homology) domain
IPR005821 Ion transport domain
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016024 Armadillo-type fold
IPR016093 MIR motif

PFAM

PF01365
PF00520
PF08454
PF08709
PF02815

PRINTS

PR00779

PIRSF

SMART

SM00472

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt