Version 5.4
Homo sapiens Gene: ITPR2
Summary
InnateDB Gene IDBG-24160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPR2
Gene Name inositol 1,4,5-trisphosphate receptor, type 2
Synonyms CFAP48; IP3R2
Species Homo sapiens
Ensembl Gene ENSG00000123104
Encoded Proteins
IDBP-24162
inositol 1,4,5-trisphosphate receptor, type 2
IDBP-24164
inositol 1,4,5-trisphosphate receptor, type 2
IDBP-370243
inositol 1,4,5-trisphosphate receptor, type 2
IDBP-596720
inositol 1,4,5-trisphosphate receptor, type 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:26336515-26833198
Strand Reverse strand
Band p11.23
Transcripts
ENST00000381340 ENSP00000370744
ENST00000242737 ENSP00000242737
ENST00000451599 ENSP00000408287
ENST00000538984
ENST00000540429
ENST00000543958
ENST00000545902
ENST00000540791
ENST00000545235 ENSP00000440548
ENST00000536627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262 calcium channel activity
GO:0005488 binding
GO:0015085 calcium ion transmembrane transporter activity
GO:0015278 calcium-release channel activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0001666 response to hypoxia
GO:0006112 energy reserve metabolic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007596 blood coagulation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030168 platelet activation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050796 regulation of insulin secretion
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071361 cellular response to ethanol
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0031095 platelet dense tubular network membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030287
View Gene Order
ENSBTAG00000002313
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_162
Elevation of cytosolic Ca2+ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_15526
G-protein mediated events pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_111217
Metabolism pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04730
Long-term depression pathway
hsa04020
Calcium signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt Q14571
TrEMBL F5GYT5 H7C2X9 I1VE21
UniProt Splice Variant
Entrez Gene 3709
UniGene Hs.512235 Hs.603480
RefSeq NM_002223 XM_006719064
HUGO HGNC:6181
OMIM 600144
CCDS CCDS41764
HPRD
IMGT
EMBL AB012610 AC023051 AC023425 AC024093 AC024145 AC055720 D26350 JQ388971
GenPept AFI41831 BAA05384 BAA33961
RNA Seq Atlas 3709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca