InnateDB Protein
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IDBP-24164.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ITPR2
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Protein Name
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inositol 1,4,5-trisphosphate receptor, type 2
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Synonyms
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CFAP48; IP3R2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000242737
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InnateDB Gene
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IDBG-24160 (ITPR2)
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Protein Structure
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Function |
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Isoform Short is found in skeletal muscle and heart.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015085
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calcium ion transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000493
Inositol 1,4,5-trisphosphate-binding protein receptor
IPR014821
Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093
MIR motif
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PFAM |
PF08709
PF02815
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PRINTS |
PR00779
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PIRSF |
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SMART |
SM00472
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TIGRFAMs |
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Modification |
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SwissProt |
Q14571
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PhosphoSite |
PhosphoSite-Q14571
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3709
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UniGene |
Hs.603480
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RefSeq |
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HUGO |
HGNC:6181
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OMIM |
600144
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CCDS |
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HPRD |
02536
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IMGT |
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EMBL |
AB012610
AC023051
AC023425
AC024093
AC024145
AC055720
D26350
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GenPept |
BAA05384
BAA33961
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