InnateDB Protein
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IDBP-241775.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC8A3
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Protein Name
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solute carrier family 8 (sodium/calcium exchanger), member 3
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Synonyms
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NCX3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377863
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InnateDB Gene
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IDBG-10629 (SLC8A3)
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Protein Structure
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Function |
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. {ECO:0000269PubMed:15777725}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004836
Sodium/calcium exchanger protein
IPR004837
Sodium/calcium exchanger membrane region
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PFAM |
PF01699
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PRINTS |
PR01259
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P57103
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PhosphoSite |
PhosphoSite-P57103
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6547
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UniGene |
Hs.715967
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RefSeq |
NP_891981
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HUGO |
HGNC:11070
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OMIM |
607991
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CCDS |
CCDS41967
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HPRD |
09723
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IMGT |
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EMBL |
AF508982
AF510501
AF510502
AF510503
AJ304852
AJ304853
AJ745101
AJ745102
AL135747
AL160191
BC142969
CH471061
X93017
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GenPept |
AAI42970
AAM90955
AAN60790
AAN60791
AAN60792
CAC40984
CAC40985
CAG33739
CAG33740
EAW81019
EAW81021
EAW81026
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