InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LHX6

Summary

InnateDB Protein

IDBP-241824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LHX6

Protein Name

LIM homeobox 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377854

InnateDB Gene

IDBG-83755 (LHX6)

Protein Structure

UniProt Annotation

Function

Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021800	cerebral cortex tangential migration
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0021877	forebrain neuron fate commitment
GO:0021884	forebrain neuron development
GO:0021895	cerebral cortex neuron differentiation
GO:0048469	cell maturation