Homo sapiens Protein: LHX6
Summary
InnateDB Protein IDBP-241824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX6
Protein Name LIM homeobox 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377854
InnateDB Gene IDBG-83755 (LHX6)
Protein Structure
UniProt Annotation
Function Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021800 cerebral cortex tangential migration
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0021877 forebrain neuron fate commitment
GO:0021884 forebrain neuron development
GO:0021895 cerebral cortex neuron differentiation
GO:0048469 cell maturation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR001781 Zinc finger, LIM-type
IPR009057 Homeodomain-like
PFAM PF00046
PF00412
PRINTS
PIRSF
SMART SM00389
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPM6
PhosphoSite PhosphoSite-Q9UPM6
TrEMBL Q3SY65
UniProt Splice Variant
Entrez Gene 26468
UniGene Hs.103137
RefSeq NP_055183
HUGO HGNC:21735
OMIM 608215
CCDS CCDS6838
HPRD 10498
IMGT
EMBL AB031041 AB031042 AK126982 AK289827 AK297175 AK299709 AK313808 AL136570 AL162424 BC103936 BC103937 BC103938 CH471090
GenPept AAI03937 AAI03938 AAI03939 BAA83422 BAA83423 BAF82516 BAG36544 BAH12516 BAH13108 CAB66505 CAI14703 CAI14704 CAO03565 CAO03566 EAW87515 EAW87516 EAW87517