Version 5.4
Homo sapiens Gene: LHX6
Summary
InnateDB Gene IDBG-83755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX6
Gene Name LIM homeobox 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106852
Encoded Proteins
IDBP-83759
LIM homeobox 6
IDBP-83761
LIM homeobox 6
IDBP-83763
LIM homeobox 6
IDBP-241824
LIM homeobox 6
IDBP-599491
LIM homeobox 6
IDBP-584687
LIM homeobox 6
IDBP-807748
LIM homeobox 6
IDBP-595049
LIM homeobox 6
IDBP-593325
LIM homeobox 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:122202577-122229626
Strand Reverse strand
Band q33.2
Transcripts
ENST00000373755 ENSP00000362860
ENST00000373754 ENSP00000362859
ENST00000340587 ENSP00000340137
ENST00000394319 ENSP00000377854
ENST00000464484 ENSP00000452811
ENST00000482062 ENSP00000453798
ENST00000559895 ENSP00000475927
ENST00000541397 ENSP00000441464
ENST00000558672
ENST00000560152
ENST00000560485 ENSP00000453606
ENST00000559529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021800 cerebral cortex tangential migration
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0021877 forebrain neuron fate commitment
GO:0021884 forebrain neuron development
GO:0021895 cerebral cortex neuron differentiation
GO:0048469 cell maturation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026890
View Gene Order
ENSBTAG00000005525
Not yet available
Cross-References
SwissProt Q9UPM6
TrEMBL H0YKH7 H0YMH3
UniProt Splice Variant
Entrez Gene 26468
UniGene Hs.103137
RefSeq NM_001242333 NM_001242334 NM_001242335 NM_014368 NM_199160 XM_005251915 XM_005251916
HUGO HGNC:21735
OMIM 608215
CCDS CCDS56584 CCDS56583 CCDS59144 CCDS6837 CCDS6838
HPRD 10498
IMGT
EMBL AB031041 AB031042 AK126982 AK289827 AK297175 AK299709 AK313808 AL136570 AL162424 BC103936 BC103937 CH471090
GenPept AAI03937 AAI03938 BAA83422 BAA83423 BAF82516 BAG36544 BAH12516 BAH13108 CAB66505 CAI14703 CAI14704 CAO03565 CAO03566 EAW87515 EAW87516
RNA Seq Atlas 26468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca