InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASNS

Summary

InnateDB Protein

IDBP-241857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASNS

Protein Name

asparagine synthetase (glutamine-hydrolyzing)

Synonyms

ASNSD; TS11;

Species

Homo sapiens

Ensembl Protein

ENSP00000377845

InnateDB Gene

IDBG-28257 (ASNS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Asparagine synthetase deficiency (ASNSD) [MIM:615574]: An inborn error of asparagine biosynthesis that results in a severe neurologic disorder characterized by microcephaly, severely delayed psychomotor development, progressive encephalopathy, cortical atrophy, and seizure or hyperekplexic activity. {ECO:0000269PubMed:24139043}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	44 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524	ATP binding

Biological Process

GO:0006529	asparagine biosynthetic process
GO:0006541	glutamine metabolic process
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0008152	metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034641	cellular nitrogen compound metabolic process
GO:0042149	cellular response to glucose starvation
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0045931	positive regulation of mitotic cell cycle
GO:0070981	L-asparagine biosynthetic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000583 Class II glutamine amidotransferase domain
IPR001962 Asparagine synthase
IPR006426 Asparagine synthase, glutamine-hydrolyzing
IPR029055 Nucleophile aminohydrolases, N-terminal

PFAM

PF00310
PF13537
PF00733

PRINTS

PIRSF

PIRSF001589

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08243