Version 5.4
Homo sapiens Protein: TSPAN3
Summary
InnateDB Protein IDBP-24196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPAN3
Protein Name tetraspanin 3
Synonyms TM4-A; TM4SF8; TSPAN-3;
Species Homo sapiens
Ensembl Protein ENSP00000267970
InnateDB Gene IDBG-24194 (TSPAN3)
Protein Structure
UniProt Annotation
Function Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60637
PhosphoSite PhosphoSite-O60637
TrEMBL H0YMH8
UniProt Splice Variant
Entrez Gene 10099
UniGene Hs.741445
RefSeq NP_005715
HUGO HGNC:17752
OMIM 613134
CCDS CCDS10292
HPRD 15512
IMGT
EMBL AC090181 AF054840 AF133423 AK001305 AK001310 AK001326 AK075336 AK075482 AK298157 BC000704 BC004280 BC009248 BC011206 CH471136
GenPept AAC69716 AAF08362 AAH00704 AAH04280 AAH09248 AAH11206 BAA91613 BAA91615 BAA91627 BAG52114 BAG52152 BAG60431 EAW99209 EAW99210 EAW99211

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca