Version 5.4
Homo sapiens Protein: DENND1A
Summary
InnateDB Protein IDBP-242011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND1A
Protein Name DENN/MADD domain containing 1A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377766
InnateDB Gene IDBG-84620 (DENND1A)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles. {ECO:0000269PubMed:20154091, ECO:0000269PubMed:20937701}.
Subcellular Localization Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269PubMed:20937701}; Peripheral membrane protein {ECO:0000269PubMed:20937701}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:20937701}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0030054 cell junction
GO:0030136 clathrin-coated vesicle
GO:0030665 clathrin-coated vesicle membrane
GO:0042734 presynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR001194 DENN domain
IPR005112 dDENN domain
PFAM PF02141
PF03455
PRINTS
PIRSF
SMART SM00799
SM00801
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TEH3
PhosphoSite PhosphoSite-Q8TEH3
TrEMBL
UniProt Splice Variant
Entrez Gene 57706
UniGene Hs.682912
RefSeq
HUGO HGNC:29324
OMIM 613633
CCDS
HPRD 17221
IMGT
EMBL AC006450 AK024782 AK074151 AK295710 AK299867 AL161790 AL390774 AL445489 BC009616 BC028061 BC039703 BK006958 CH471090
GenPept AAH09616 AAH28061 AAH39703 BAB15002 BAB84977 BAH12164 BAH13155 CAH73637 CAH73638 CAH73640 CAI15705 CAI15706 CAI15707 CAI39791 CAI39792 CAI39794 DAA12500 EAW87571 EAW87575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca