InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST3GAL6

Summary

InnateDB Protein

IDBP-242160.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST3GAL6

Protein Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Synonyms

SIAT10; ST3GALVI;

Species

Homo sapiens

Ensembl Protein

ENSP00000377717

InnateDB Gene

IDBG-46999 (ST3GAL6)

Protein Structure

UniProt Annotation

Function

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008373	sialyltransferase activity
GO:0052798	beta-galactoside alpha-2,3-sialyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006464	cellular protein modification process
GO:0006486	protein glycosylation
GO:0006664	glycolipid metabolic process
GO:0009311	oligosaccharide metabolic process
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0044281	small molecule metabolic process
GO:0071354	cellular response to interleukin-6
GO:0097503	sialylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane
GO:0070062	extracellular vesicular exosome