InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ST3GAL6

Summary

InnateDB Gene

IDBG-46999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST3GAL6

Gene Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Synonyms

SIAT10; ST3GALVI

Species

Homo sapiens

Ensembl Gene

ENSG00000064225

Encoded Proteins

IDBP-47001

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-242160

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-480305

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-476627

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-477890

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-480681

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-480202

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-482189

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-483630

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-479348

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-474997

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-477720

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-482345

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-482745

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-481789

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-475581

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

IDBP-808607

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5\'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:98732236-98821201

Strand

Forward strand

Band

q12.1

Transcripts

ENST00000265261	ENSP00000265261
ENST00000394162	ENSP00000377717
ENST00000489112
ENST00000483910	ENSP00000417376
ENST00000460774	ENSP00000419209
ENST00000469105	ENSP00000419690
ENST00000466482
ENST00000462152
ENST00000486249	ENSP00000420047
ENST00000497008	ENSP00000417584
ENST00000486334	ENSP00000418896
ENST00000497621	ENSP00000418581
ENST00000480133
ENST00000465004
ENST00000476833	ENSP00000417109
ENST00000468553	ENSP00000420474
ENST00000490684
ENST00000485391	ENSP00000418650
ENST00000495376	ENSP00000420693
ENST00000492254	ENSP00000417201
ENST00000477574	ENSP00000419987
ENST00000485145	ENSP00000419202
ENST00000474595
ENST00000477899
ENST00000493953
ENST00000491912
ENST00000495502
ENST00000613264	ENSP00000480884

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008373	sialyltransferase activity
GO:0052798	beta-galactoside alpha-2,3-sialyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006464	cellular protein modification process
GO:0006486	protein glycosylation
GO:0006664	glycolipid metabolic process
GO:0009311	oligosaccharide metabolic process
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0044281	small molecule metabolic process
GO:0071354	cellular response to interleukin-6
GO:0097503	sialylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022747

View Gene Order

ENSBTAG00000004471

Not yet available

Pathways

NETPATH

REACTOME

REACT_118798

Pre-NOTCH Processing in Golgi pathway

REACT_22433

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_121120

Keratan sulfate biosynthesis pathway

REACT_147853

Mucopolysaccharidoses pathway

REACT_22161

Post-translational protein modification pathway

REACT_118744

Pre-NOTCH Expression and Processing pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_267711

Defective B4GALT7 causes EDS, progeroid type pathway

REACT_267713

Defective CHST6 causes MCDC1 pathway

REACT_121288

Keratan sulfate/keratin metabolism pathway

REACT_147719

MPS VI - Maroteaux-Lamy syndrome pathway

REACT_267645

Defective PAPSS2 causes SEMD-PA pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_147749

MPS IIID - Sanfilippo syndrome D pathway

REACT_22387

Synthesis of substrates in N-glycan biosythesis pathway

REACT_267662

Defective SLC26A2 causes chondrodysplasias pathway

REACT_111102

Signal Transduction pathway

REACT_200874

Sialic acid metabolism pathway

REACT_147739

MPS IX - Natowicz syndrome pathway

REACT_267674

Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway

REACT_17015

Metabolism of proteins pathway

REACT_267642

Defective CHST14 causes EDS, musculocontractural type pathway

REACT_147798

MPS IV - Morquio syndrome B pathway

REACT_267659

Defective B3GAT3 causes JDSSDHD pathway

REACT_267708

Defective CHST3 causes SEDCJD pathway

REACT_147825

MPS IV - Morquio syndrome A pathway

REACT_267654

Defective EXT2 causes exostoses 2 pathway

REACT_267707

Diseases associated with glycosaminoglycan metabolism pathway

REACT_147734

MPS II - Hunter syndrome pathway

REACT_299

Signaling by NOTCH pathway

REACT_267635

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway

REACT_121315

Glycosaminoglycan metabolism pathway

REACT_267705

Diseases of glycosylation pathway

REACT_147759

MPS VII - Sly syndrome pathway

REACT_267682

Defective CHSY1 causes TPBS pathway

REACT_111217

Metabolism pathway

REACT_147857

MPS I - Hurler syndrome pathway

REACT_147753

MPS IIIA - Sanfilippo syndrome A pathway

REACT_147860

MPS IIIC - Sanfilippo syndrome C pathway

REACT_116125

Disease pathway

REACT_200833

Glycogen storage diseases pathway

REACT_147788

MPS IIIB - Sanfilippo syndrome B pathway

KEGG

hsa00601

Glycosphingolipid biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.611523

RefSeq

NM_001271142 NM_001271145 NM_001271146 NM_001271147 NM_006100 XM_005247068 XM_005247069 XM_005247070 XM_005247072 XM_006713475

HUGO

OMIM

CCDS

CCDS2933 CCDS59452 CCDS74968

HPRD

06195

IMGT

EMBL

GenPept

RNA Seq Atlas