InnateDB Protein
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IDBP-242188.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CSF3
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Protein Name
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colony stimulating factor 3 (granulocyte)
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Synonyms
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C17orf33; CSF3OS; GCSF;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377705
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InnateDB Gene
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IDBG-46887 (CSF3)
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Protein Structure
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Function |
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
5
[view]
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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|
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Molecular Function |
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Biological Process |
GO:0006955
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immune response
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GO:0007275
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multicellular organismal development
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GO:0014068
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positive regulation of phosphatidylinositol 3-kinase signaling
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GO:0019221
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cytokine-mediated signaling pathway
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GO:0030838
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positive regulation of actin filament polymerization
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GO:0030851
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granulocyte differentiation
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GO:0032092
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positive regulation of protein binding
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GO:0033138
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positive regulation of peptidyl-serine phosphorylation
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GO:0042993
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positive regulation of transcription factor import into nucleus
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0051897
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positive regulation of protein kinase B signaling
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GO:0071345
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cellular response to cytokine stimulus
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GO:2000251
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positive regulation of actin cytoskeleton reorganization
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Cellular Component |
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PDB ID |
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InterPro |
IPR003573
Interleukin-6/Interleukin-23/GCSF/MGF
IPR009079
Four-helical cytokine-like, core
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PFAM |
PF00489
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PRINTS |
PR00433
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PIRSF |
PIRSF001935
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SMART |
SM00126
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TIGRFAMs |
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Modification |
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SwissProt |
P09919
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PhosphoSite |
PhosphoSite-P09919
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TrEMBL |
Q6FH65
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UniProt Splice Variant |
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Entrez Gene |
1440
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UniGene |
Hs.2233
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RefSeq |
NP_757373
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HUGO |
HGNC:2438
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OMIM |
138970
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CCDS |
CCDS42314
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HPRD |
00736
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IMGT |
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EMBL |
AC090844
AF388025
AK313509
CD013926
CH471152
CR541891
M13008
M17706
X03438
X03655
X03656
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GenPept |
AAA03056
AAA35882
AAK62469
BAG36289
CAA27168
CAA27290
CAA27291
CAG46689
EAW60628
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