Version 5.4
Homo sapiens Gene: CSF3
Summary
InnateDB Gene IDBG-46887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF3
Gene Name colony stimulating factor 3 (granulocyte)
Synonyms C17orf33; CSF3OS; GCSF
Species Homo sapiens
Ensembl Gene ENSG00000108342
Encoded Proteins
IDBP-46889
colony stimulating factor 3 (granulocyte)
IDBP-46891
colony stimulating factor 3 (granulocyte)
IDBP-242188
colony stimulating factor 3 (granulocyte)
IDBP-242190
colony stimulating factor 3 (granulocyte)
IDBP-764658
IDBP-761204
IDBP-763430
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40015361-40017813
Strand Forward strand
Band q21.1
Transcripts
ENST00000225474 ENSP00000225474
ENST00000331769 ENSP00000327766
ENST00000394149 ENSP00000377705
ENST00000394148 ENSP00000377704
ENST00000479880
ENST00000582798
ENST00000577675 ENSP00000462991
ENST00000579852 ENSP00000464157
ENST00000583218 ENSP00000464421
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 1 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005130 granulocyte colony-stimulating factor receptor binding
GO:0008083 growth factor activity
GO:0019899 enzyme binding
Biological Process
GO:0006955 immune response
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019221 cytokine-mediated signaling pathway
GO:0030838 positive regulation of actin filament polymerization
GO:0030851 granulocyte differentiation
GO:0032092 positive regulation of protein binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0071222 cellular response to lipopolysaccharide
GO:0071345 cellular response to cytokine stimulus
GO:1901215 negative regulation of neuron death
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038067
View Gene Order
ENSBTAG00000021462
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05144
Malaria pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.2233
RefSeq NM_000759 NM_001178147 NM_172219 NM_172220
HUGO
OMIM
CCDS CCDS11357 CCDS11358 CCDS42314
HPRD 00736
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca