InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR112

Summary

InnateDB Protein

IDBP-242192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR112

Protein Name

G protein-coupled receptor 112

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377699

InnateDB Gene

IDBG-87560 (GPR112)

Protein Structure

UniProt Annotation

Function

Orphan receptor.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma. {ECO:0000269PubMed:18953328}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR001759 Pentaxin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR017981 GPCR, family 2-like

PFAM

PF01825
PF00002
PF00354

PRINTS

PR00249
PR00895

PIRSF

SMART

SM00303
SM00159

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt