Version 5.4
Homo sapiens Gene: GPR112
Summary
InnateDB Gene IDBG-87560.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR112
Gene Name G protein-coupled receptor 112
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156920
Encoded Proteins
IDBP-87562
G protein-coupled receptor 112
IDBP-242192
G protein-coupled receptor 112
IDBP-242194
G protein-coupled receptor 112
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:136300963-136416888
Strand Forward strand
Band q26.3
Transcripts
ENST00000370652 ENSP00000359686
ENST00000394143 ENSP00000377699
ENST00000394141 ENSP00000377697
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000053852
View Gene Order
Cross-References
SwissProt Q8IZF6
TrEMBL
UniProt Splice Variant
Entrez Gene 139378
UniGene Hs.381354
RefSeq XM_005262367 NM_153834
HUGO HGNC:18992
OMIM
CCDS CCDS35409
HPRD 06578
IMGT
EMBL AL078638 AL136167 AL161778 AY140954 AY255581 AY882585
GenPept AAN46668 AAO85093 AAW78659 CAI40998 CAM21249 CAM21579 CAM21580 CAM28220 CAM28221
RNA Seq Atlas 139378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca