InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCTN1

Summary

InnateDB Protein

IDBP-242465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCTN1

Protein Name

dynactin 1

Synonyms

DAP-150; DP-150; P135;

Species

Homo sapiens

Ensembl Protein

ENSP00000377571

InnateDB Gene

IDBG-57205 (DCTN1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	111 [view]
Protein-Protein	111 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0045502	dynein binding
GO:0048037	cofactor binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007067	mitotic nuclear division
GO:0007399	nervous system development
GO:0008219	cell death
GO:0010970	microtubule-based transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000776	kinetochore
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005869	dynactin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030286	dynein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000938 CAP Gly-rich domain
IPR015083 Polyketide synthase, docking domain
IPR022157 Dynein associated protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01302
PF08990
PF12455

PRINTS

PIRSF

SMART

SM01052

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14203