Version 5.4
Homo sapiens Gene: DCTN1
Summary
InnateDB Gene IDBG-57205.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCTN1
Gene Name dynactin 1
Synonyms DAP-150; DP-150; P135
Species Homo sapiens
Ensembl Gene ENSG00000204843
Encoded Proteins
IDBP-57207
dynactin 1
IDBP-242465
dynactin 1
IDBP-295506
dynactin 1
IDBP-295515
dynactin 1
IDBP-295517
dynactin 1
IDBP-295514
dynactin 1
IDBP-380566
dynactin 1
IDBP-380578
dynactin 1
IDBP-380579
dynactin 1
IDBP-380581
dynactin 1
IDBP-380582
dynactin 1
IDBP-380586
dynactin 1
IDBP-380589
dynactin 1
IDBP-380590
dynactin 1
IDBP-380592
dynactin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74361154-74392087
Strand Reverse strand
Band p13.1
Transcripts
ENST00000361874 ENSP00000354791
ENST00000394003 ENSP00000377571
ENST00000409567 ENSP00000386843
ENST00000409240 ENSP00000386406
ENST00000409868 ENSP00000387327
ENST00000409438 ENSP00000387270
ENST00000434055 ENSP00000416711
ENST00000458655 ENSP00000414315
ENST00000454119 ENSP00000404038
ENST00000417090 ENSP00000402509
ENST00000437375 ENSP00000395312
ENST00000421392 ENSP00000409363
ENST00000413111 ENSP00000413268
ENST00000440727 ENSP00000400059
ENST00000449655 ENSP00000407484
ENST00000491465
ENST00000497666
ENST00000466110
ENST00000492717
ENST00000495895
ENST00000495643
ENST00000470351
ENST00000463583
ENST00000477966
ENST00000462813
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 111 [view]
Protein-Protein 111 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0045502 dynein binding
GO:0048037 cofactor binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007067 mitotic nuclear division
GO:0007399 nervous system development
GO:0008219 cell death
GO:0010970 microtubule-based transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032402 melanosome transport
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000776 kinetochore
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005869 dynactin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0030286 dynein complex
GO:0031252 cell leading edge
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031865
View Gene Order
ENSBTAG00000004887
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa05016
Huntington's disease pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516111 Hs.740125
RefSeq NM_001135040 NM_001135041 NM_001190836 NM_001190837 NM_004082 NM_023019
HUGO
OMIM
CCDS CCDS1939 CCDS46341 CCDS46342 CCDS54368 CCDS54369
HPRD 07206
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca