Version 5.4
Homo sapiens Protein: ELMO3
Summary
InnateDB Protein IDBP-242483.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELMO3
Protein Name engulfment and cell motility 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377566
InnateDB Gene IDBG-36322 (ELMO3)
Protein Structure
UniProt Annotation
Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0006909 phagocytosis
GO:0006915 apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR006816 Engulfment/cell motility, ELMO
IPR016024 Armadillo-type fold
IPR024574 Domain of unknown function DUF3361
PFAM PF04727
PF11841
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96BJ8
PhosphoSite PhosphoSite-Q96BJ8
TrEMBL
UniProt Splice Variant
Entrez Gene 79767
UniGene Hs.377416
RefSeq NP_078988
HUGO HGNC:17289
OMIM 606422
CCDS CCDS10833
HPRD 12104
IMGT
EMBL AC040160 AK023886 AK300976 BC015524 BC034410
GenPept AAH15524 AAH34410 BAB14712 BAG62598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca